Pulmonary vasoconstriction and profound leukopenia in two sheep experimental models. Effects of complement depletion.
نویسندگان
چکیده
24S Lung Defense, Injury and Repair Mechanisms of lung microvascular injury. Ann New York Acad Sci 1982; 384:319-31 4 Malik AR, van der Zee H. Lung vascular permeability following progressive pulmonary microembolization. J Appi Physiol 1978; 45:590-97 5 Kaplan A?, Silverberg M, Dunn JT, Ghebrehiwet B. In: Kushner I, Volankis JE, Gewurz H, eds, C-reactive protein and the plasma protein response to tissue injury. Ann New York Acad Sci 1982; 389:25-38 6 Malik AR, Johnson A, Tahamont MV. Mechanisms of lung vascular injury after intravascular coagulation. In: Malik AB, Staub NC, eds, Mechanism of lung vascular injury. Ann New York Acad Sci 1982; 384:213-34 7 Jacobs HS, Craddock PR, Hammerschmidt DE, Moldow CF. Complement-induced granulocyte aggregation. N EngI J Med 1980; 302:789-74
منابع مشابه
Acute pulmonary vasoconstriction and thromboxane release during protamine reversal of heparin anticoagulation in awake sheep. Evidence for the role of reactive oxygen metabolites following nonimmunological complement activation.
When protamine (2 mg/kg) was injected intravenously into awake sheep 5 minutes after infusing heparin (200 units/kg), there was transient diffuse pulmonary vasoconstriction with mean pulmonary arterial pressure increasing from 18.0 +/- 0.7 to 43.8 +/- 2.7 mm Hg at 1 minute (x +/- SEM; n = 10). In addition, there was profound leukopenia (36.9 +/- 7.7% of baseline values at 2 minutes) with transp...
متن کاملThromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep.
Infusion into sheep of plasma containing zymosan-activated complement produces leukopenia, pulmonary leukostasis, and pulmonary artery hypertension. We previously demonstrated a close relationship between the pulmonary vascular response and elevations of plasma thromboxane. We have investigated the source of thromboxane synthesis in this model. Plasma containing zymosan-activated complement add...
متن کاملPulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits.
Pulmonary leukostasis, as a result of complement activation, has been invoked as a cause of pulmonary dysfunction. To investigate this phenomenon, we studied the pulmonary response to infusion of autologous complement-activated plasma in sheep and rabbits. Complement activation was produced by plasma incubation with zymosan. Leukopenia, with selective loss of polymorphonuclear leukocytes into t...
متن کاملThromboxane receptor blockade prevents pulmonary hypertension induced by heparin-protamine reactions in awake sheep.
We used competitive thromboxane A2-prostaglandin endoperoxide receptor blockade (SQ 30,741) as a probe to evaluate the role of thromboxane in ovine pulmonary vasoconstriction associated with protamine reversal of heparin anticoagulation. Control heparin-protamine reactions induced rapid release of thromboxane into arterial plasma (more than 1 ng/ml plasma), a 2.5-fold increase of pulmonary arte...
متن کاملSustained Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Rat Lung: Effect of α1-adrenergic Receptor Agonist
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chest
دوره 83 5 Suppl شماره
صفحات -
تاریخ انتشار 1983